Laboratory studies of the impact of calcite on in vitro and in vivo effects of coal dust: A potential preventive agent for coal workers' pneumoconiosis?
Background Bioavailable iron (BAI) in coal, which may play a key role in causing coal
workers' pneumoconiosis (CWP), is present at relatively high levels in Appalachian coals.
Calcite decreases BAI and is more plentiful in Western coals than in Appalachian coals,
possibly explaining the lower CWP prevalence among Western miners. Methods We
measured effects of calcite on BAI in non‐cellular and cellular systems involving
Pennsylvania (PA) coal dust. We also tested in vivo effects of calcite on transferrin receptor …
workers' pneumoconiosis (CWP), is present at relatively high levels in Appalachian coals.
Calcite decreases BAI and is more plentiful in Western coals than in Appalachian coals,
possibly explaining the lower CWP prevalence among Western miners. Methods We
measured effects of calcite on BAI in non‐cellular and cellular systems involving
Pennsylvania (PA) coal dust. We also tested in vivo effects of calcite on transferrin receptor …
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